ITRAVIL AP CLOBENZOREX 60MG 60TABS

Clobenzorex is a sympathomimetic amine that acts on the ventrolateral nucleus of the hypothalamus, increasing the release of norepinephrine and dopamine in the synaptic spaces and decreasing their reuptake in presynaptic nerve endings, so the net effect is an increase in norepinephrine concentrations. and dopamine. Norepinephrine basically acts to curb appetite by activating alpha 4 and beta 1 receptors in the hypothalamic nuclei. Three main mechanisms have been identified by which drugs contribute to weight and body fat reduction:

a) Decreased food intake.

b) Specific metabolic modifications.

c) Increased energy expenditure.

Clobenzorex is well absorbed from the digestive tract, the peak concentration of Clobenzorex is reached 50 to 120 minutes after the first dose and the concentration varies from 8 to 47 ng/ml. Elimination is via the kidneys in the form of para-hydroxyclobenzorex.